Bill Evans learned valuable lessons as his wife, Jacquelyn, battled Alzheimer’s disease. The Houston man wants to share what he’s learned while caring for his wife of 46 years in her final days before her passing on Aug. 7 at age 74. “We have to make people more aware of what the disease is all […]
COLUMBIANA Patricia Lois Lockwood Evans, a beloved member of the community, peacefully passed away at her home, Friday, Feb. 9, 2024, at the age of 95. Her
E-Mail
Mutations in two genetic regions in dogs explain over one third of the risk of developing an aggressive form of hematological cancer, according to a study led by Jacquelyn Evans and Elaine Ostrander at the National Human Genome Research Institute in Maryland, USA and colleagues. The study, which combined multiple sequencing techniques to investigate histiocytic sarcoma in retriever dogs, publishes May 13 in the open-access journal
PLOS Genetics.
Histiocytic sarcoma is an aggressive cancer of immune cells, and although extremely rare in humans, it affects around one-in-five flat-coated retrievers. Genome-wide association surveys of 177 affected and 132 unaffected flat-coated retrievers identified two loci on chromosomes 5 and 19 of the canine genome associated with histiocytic sarcoma. Whole genome, transcriptome, and chromatin immunoprecipitation (CHiP) sequence data revealed that the CFA5 locus contains mutations near a known tumor-suppressor gene, PIK3R6. CFA5 also