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IMAGE: Normal liver tissues (left) do not produce mesothelin, while liver tissue from patients with primary sclerosing cholangitis do (right, darker staining). Mesothelin is a marker of liver fibrosis, and the. view more
Credit: UC San Diego Health Sciences
Chronic alcohol abuse and hepatitis can injure the liver and lead to fibrosis, the buildup of collagen and scar tissue. As a potential approach to treating liver fibrosis, University of California San Diego School of Medicine researchers and their collaborators are looking for ways to stop liver cells from producing collagen. So we thought.what if we take immunotoxins and try to get them to kill collagen-producing cells in the liver, said team lead Tatiana Kisseleva, MD, PhD, associate professor of surgery at UC San Diego School of Medicine. If these antibodies carrying toxic molecules can find and bind the cells, the cells will eat up the gift and die.
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