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Antisense Oligo Therapy Dampens Metabolic Consequences of High-Fat Diet and Obesity March 15, 2021 Share Consuming a high-fat diet (HFD) is linked with increased risk for obesity and associated metabolic disorders, including type 2 diabetes, cardiovascular diseases, and fatty liver. Studies by researchers at the Karolinska Institutet in Sweden have now shown that the damaging effects of a high-fat diet can be reversed in mice, by treating the animals with an antisense oligonucleotide (ASO) that reduces levels of apolipoprotein CIII (apoCIII), a key regulator of lipid metabolism. Reporting on their studies in Science Advances, first author Ismael Valladolid-Acebes, PhD, assistant professor at the department of molecular medicine and surgery, Karolinska Institutet, and colleagues, said the studies demonstrated that interfering with the HFD-induced increase in apoCIII in mice prevented the development of obesity and type 2 diabetes mellitus (T2DM), and point to apoCIII as a potent

United statesKarolinska institutetIsmael valladolid acebesLisa juntti berggrenRolf luft research centerScience advancesஒன்றுபட்டது மாநிலங்களில்இஸ்மாயில் வல்லாடோலிட்ரோல்ஃப் லஃப்ட் ஆராய்ச்சி மையம்