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<p>A new paper in <em>Genome Biology and Evolution</em>&nbsp;finds that the link between paternal age and rare congenital disorders is more complex than scientists had previously thought. While researchers have long realized that older fathers are more likely to have children with bone and heart malformations, such as Achondroplasia, Apert, or Noonan syndrome, or neurodevelopmental disorders, schizophrenia, and autism, new examination indicates that while the link between some pathogenic mutations increases with paternal age, others do not and may even occur in the father&rsquo;s testis before sexual maturity.</p>

Daniel luzerIrene tiemann boegeJohannes kepler universityInstitute of biophysicsMethod of researchOxford universityOxford university pressGenome biology