While studying how memories are stored in the brain, a team identified a novel protein folding mechanism that is essential for long-term memory storage.
A University of Iowa neuroscience research team has identified a fundamental biochemical mechanism underlying memory storage and has linked this mechanism to cognitive deficits in mouse models of Alzheimer's Disease and Related Dementias.
Researchers at the University of Iowa have identified a novel protein folding mechanism in the endoplasmic reticulum that is essential for long-term memory storage and has linked this mechanism to cognitive deficits in mouse models of Alzheimer’s disease and related dementias.
A novel protein folding mechanism in the endoplasmic reticulum is essential for long-term memory storage. This mechanism is impaired in tau-models of Alzheimer's disease, but restoring the protein folding mechanism reverses memory impairment associated with dementia.