Maintaining rational expectations about psychedelic interventions bmj.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from bmj.com Daily Mail and Mail on Sunday newspapers.
Florian Naudet and colleagues argue that routine registration of observational research is needed and suggest how current processes can be adapted to facilitate it
From the use of booster doses against covid-191 to approval of novel cancer therapies,2 health authorities and health technology assessment bodies are increasingly relying on non-randomised trials and observational studies. The methodological problems of observational studies, such as residual confounding,3 are difficult to resolve, but concerns about transparency and reliability can be reduced through registration.
Registration is an open science practice whereby research hypotheses, elements of study design, and planned statistical analyses are prespecified, preferably in a centralised repository. Registration has become the norm for clinical trials (interventional studies),4 and some have called for it to be adopted for observational studies.56 However, opponents argue that systematic registration is unrealistic, unnece
Reimagine Biomedical Research for a Healthier Future: Announcing Essay Challenge Winners and Symposium plos.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from plos.org Daily Mail and Mail on Sunday newspapers.
Absolutely Maybe
We’re into the 12th month since sequencing of the genome of SARS-Cov-2, the virus that causes Covid-19. And we have 2 Covid vaccines across the line of convincing phase 3 trial results released, plus emergency use authorization or approval. How far are we now, and why did some sprint ahead while others fell behind? Let’s start with what we know from the handful of vaccines with at least some data released.
Main takeaways about Covid vaccines so far
There are important, often major, differences in the characteristics and effects of the vaccines.
2 vaccines have been convincingly shown to have high efficacy against getting sick with Covid-19 – BNT/Pfizer’s and NIH/Moderna’s.