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Machine Learning-Based Prognostic Model for Hodgkin Lymphoma Outperforms Other Models

Machine Learning-Based Prognostic Model for Hodgkin Lymphoma Outperforms Other Models
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International prognostic scoreDanish national lymphoma registerSwedish lymphoma registerCancer registry

Brentuximab Vedotin Combo Elicits Responses in Advanced Classical Hodgkin Lymphoma

Brentuximab vedotin plus nivolumab, doxorubicin, and dacarbazine was found to have efficacy and acceptable safety and tolerability when used as a frontline treatment in patients with previously untreated advanced, classical Hodgkin lymphoma.

United statesHun ju leeDepartment of lymphoma myelomaInternational prognostic scoreUniversity of texas md anderson cancer centerCancer centerCart cell therapy2023 ash annual meetingClassical hlPhase 2 sgn35 027 trial nct03646123

Brentuximab Vedotin Plus AVD Gets Positive CHMP Opinion for CD30+ Stage III Hodgkin Lymphoma

The European Medicine Agency’s Committee for Medicinal Products for Human Use has recommended the approval of brentuximab vedotin in combination with doxorubicin, vinblastine, and dacarbazine in adult patients with previously untreated, CD30-positive, stage III Hodgkin lymphoma.

United statesInternational prognostic scoreSeattle genetics incWorld health organizationEuropean commissionEuropean medicine agencyMedicinal productsHuman useAnn arborBrentuximab vedotinD30 stage iii hodgkin lymphomaNd dacarbazine

Adcetris Improves Lymphoma Outcomes, Regardless of PET Scan Results

While PET scans have been used to predict Hodgkin lymphoma outcomes, adding Adcetris to frontline therapy improved outcomes for patients, regardless of their results.

Ravand samaeekiaSchool of hematologic oncologyInternational prognostic scoreLoma linda university internal medicineLoma linda university cancer centerAdding adcetrisHematologic oncologyLoma linda university cancerAnn arbor stageHodgkin lymphoma

Data Suggest Interim PET2 Scans Can be Omitted for Frontline Brentuximab Vedotin Regimens in Hodgkin Lymphoma

The incorporation of brentuximab vedotin (Adcetris) into the frontline treatment of patients with Hodgkin lymphoma correlates with superior efficacy, irrespective of PET2 results, suggesting loss of predictive value with the scan.

United statesRavand samaeekiaLoma linda university internal medicineInternational prognostic scoreLoma linda university cancer centerLoma linda university cancerAnn arbor stageBrentuximab vedotinHodgkin lymphomaPet2 scansHematologic malignancies