Most patients in the cohort received rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone for first-line therapy; hospitalization was prevalent; and average medical and pharmacy costs were more than $140,000 per patient per year.
When plans for the DSM-5 were first announced about ten years ago, most folks’ reaction was “Why?”. Many of us asked that same question several times as the publication date for the new tome kept on getting pushed back. Finally, the curtain enshrouding the DSM-5 Task Force and its several committees began to part and proposed revisions/additions began to appear on its website. To our dismay, we found our question answered.
Why the mental health of teens collapsed at the same time and in the same way in the USA, the UK, Canada, Australia, and New Zealand. By Zach Rausch and Jon Haidt.
Comprehensive new guidelines recommend physical and psychological treatments, and supported self care
Temporomandibular disorders (TMDs) are among the most common cause of chronic orofacial pain (pain lasting over three months).1 Chronic TMDs have a number of subtypes where the temporomandibular joint (TMJ), muscles of mastication, and adjacent structures may be variably affected. They are classed as a primary pain condition in the new chronic pain coding system of the International Classification of Disease , 11th revision.2 The demand for clinical guidance on TMDs management is clear: there have been five recent guidelines,34567 each with some identified limitations, plus nine previous network meta-analyses, which either investigated only a subset of interventions8910111213 or specific subtypes of TMDs.10131415 With more than 50 possible interventions identified, there is an urgent need for clear, comprehensive, evidence-based guidance to ensure that people with TMDs receive timely