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Seven findings that could save the NHS money and improve care

Discover seven research findings that could save the NHS money while also improving care

United kingdomJemma kwintLauren hoskinCare researchDepartment of healthCare delivery researchCare national auditResearch centreNational institute for healthHealth technology assessmentNational instituteTerm planIntensive care national auditCare excellenceTechnology assessmentSocial care delivery research

Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial

In patients hospitalised for COVID-19 with clinical hypoxia who required either no oxygen or simple oxygen only, higher dose corticosteroids significantly increased the risk of death compared with usual care, which included low-dose corticosteroids. The RECOVERY trial continues to assess the effects of higher dose corticosteroids in patients hospitalised with COVID-19 who require non-invasive ventilation, invasive mechanical ventilation, or extracorporeal membrane oxygenation.

United kingdomNorthern irelandRaphl hamersDamodar paudelPeterw horbyMarian knightEdmund juszczakRichard haynesMark campbellRoshan kumar jhaEvelyne kestelynMarion mafhamDavid demetsThomas jakiMayah buchSauln faust

Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support–Free Days in Patients Hospitalized With COVID-19: A Randomized Clinical Trial | Critical Care Medicine | JAMA

This randomized clinical trial examines the effect of initiation of a renin-angiotensin system inhibitor (ACE inhibitor or an angiotensin receptor blocker) on t

Eteläuomen läiSaudi arabiaSri lankaUniversity of minnesotaUnited statesSan franciscoNew south walesCity ofUnited kingdomKrung thep mahanakhonBritish columbiaFrance generalNew zealandWestern australiaNorthern irelandSouth australia

Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial

Molnupiravir did not reduce the frequency of COVID-19-associated hospitalisations or death among high-risk vaccinated adults in the community.

City ofUnited kingdomNorthern irelandYusuf soniJulianne brownMike butlerOlajide popoolaGreg irvingDivya shahAfsana safaJames kennardSarit ghoshSatash sehdevOmair razzaqUmar khanScot richardson

Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial | Critical Care Medicine | JAMA

This secondary analysis of an ongoing adaptive platform trial examines the effect of multiple interventions for critically ill adults with COVID-19 on longer-te

United kingdomSouth australiaFrance generalCity ofBritish columbiaUnited statesWestern australiaSan franciscoNew zealand generalNew zealandEstado de pernambucoNational universityEteläuomen läiSao pauloSri lankaAr riya

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