Non-communicable disease co-morbidity and associated factors in tuberculosis patients: A cross-sectional study in Gabon thelancet.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from thelancet.com Daily Mail and Mail on Sunday newspapers.
Sleep Apnea Syndrome (SAS) is one of the most common chronic diseases, affecting nearly one billion people worldwide. The repetitive occurrence of abnormal respiratory events generates cyclical desaturation-reoxygenation sequences known as intermittent hypoxia (IH). Among SAS metabolic sequelae, it has been established by experimental and clinical studies that SAS is an independent risk factor for the development and progression of non-alcoholic fatty liver disease (NAFLD). The principal goal of this study was to decrypt the molecular mechanisms at the onset of IH-mediated liver injury. To address this question, we used a unique mouse model of SAS exposed to IH, employed unbiased high-throughput transcriptomics and computed network analysis. This led us to examine hepatic mitochondrial ultrastructure and function using electron microscopy, high-resolution respirometry and flux analysis in isolated mitochondria. Transcriptomics and network analysis revealed that IH reprograms Nuclear Re
Prof (Dr) Sanjay Kumar Bhasin Although there are hardly any lacunae in the observations and recommendations of the High-Powered committee for overall improvement in healthcare delivery system and medical education in JKUT, yet in view of wide range of suggestions a priority needs to be decided to accomplish the targets that are to be set by the decision makers on the basis of these recommendations. My main points in this regard are: Teaching Institutions not Treatment Centers: Producing quality graduate […]