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Early-stage lung cancer coopts macrophages to help tumors invade lung tissues Immune cells that normally repair tissues in the body can be fooled by tumors when cancer starts forming in the lungs and instead help the tumor become invasive, according to a surprising discovery reported by Mount Sinai scientists in Nature in June. The researchers found that early-stage lung cancer tumors coopt the immune cells, known as tissue-resident macrophages, to help invade lung tissue. They also mapped out the process, or program, of how the macrophages allows a tumor to hurt the tissues the macrophage normally repairs. This process allows the tumor to hide from the immune system and proliferate into later, deadly stages of cancer.

Miriam meradEmily hendersonHuman immune monitoring centerMount sinai human immune monitoring centerIcahn school of medicine at mount sinaiPrecision immunology instituteMember of the institute thoracic oncologyInstitute of thoracic oncologyTisch cancer institute at mount sinaiMount sinaiIcahn schoolThoracic oncologyTisch cancer instituteஎமிலி ஹென்டர்சன்மனிதன் நோய் எதிர்ப்பு சக்தி கண்காணிப்பு மையம்ஏற்ற சினை மனிதன் நோய் எதிர்ப்பு சக்தி கண்காணிப்பு மையம்