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Charité Study Reveals Cellular Handling of Extra Chromosomes

How yeasts manage to compensate for the genetic imbalance of extra chromosomes

Having extra chromosomes is typically an issue for an organism and can disrupt development or cause disease. But some cells benefit instead. For example, cancer cells or pathogenic yeasts can use extra chromosomes to escape treatment and become drug-resistant.

Charité study in Nature: How cells deal with too many chromosomes – AfricaNewsAnalysis

Key mechanism that increases drug tolerance among microbial communities revealed

Research from the Francis Crick Institute has revealed a key mechanism which increases tolerance to drugs amongst microbial communities.

Researchers examine proteins involved in SARS-CoV-2 infection

Researchers examine proteins involved in SARS-CoV-2 infection Like all viruses, the novel coronavirus is dependent on help from the human host cell. Proteins are the functional units of the cell and enable the virus to enter the host cell or help the virus to replicate. Scientists from Charité - Universitätsmedizin Berlin and from the Berlin Institute of Health (BIH), along with colleagues from the United Kingdom, Germany and the United States, have examined the corresponding genes of the helper proteins in a large study. They discovered numerous variants that influence the amount or function of the proteins as well as their ability to support the virus. The gene variants reveal potential target structures for new drugs. The researchers have now published their results in the journal