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IMAGE: Members of the Translational mechanisms of fear memory research group, led by Raül Andero, (third from the left) at the INc-UAB. view more
Credit: INc-UAB
A research team from the Institut de Neurociències at the Universitat Autònoma de Barcelona (INc-UAB) has showed that inhibition through a drug of the Tac2 neuronal circuit, involved in the formation of the memory of fear, has opposite effects on the ability to remember aversive events in mice according to sex: it is reduced in male mice and increased in female mice.
Is the first time that a drug has been shown to produce this opposite effect on the memory of male and female mice. The study also evidences that opposing molecular mechanisms and behaviours can occur in memory formation depending on sex. The study has been published in
Same drug can have opposite effects on memory according to sexual differences
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