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From the 1933 classic The Invisible Man to the more recent Harry Potter series, devices that achieve invisibility have been popular parts of film fantasy. In recent years, scientists using special types of meta materials have shown that fantasy invisibility could one day become reality.
Invisibility is all the rage in 2008 but according to a new paper in the latest issue of Optics Express, current techniques are already obsolete.
Certain materials underneath an invisibility cloak would allow invisible objects to be seen again and a group of Chinese researchers are already working on an anti-cloak to cancel out your invisibility. Cloaking is an important problem since invisibility can help survival in hostile environment, says Huanyang Chen of Shanghai Jiao Tong University in China.
Abstract
Single-cell whole-genome sequencing (WGS) is critical for characterizing dynamic intercellular changes in DNA. Current sample preparation technologies for single-cell WGS are complex, expensive, and suffer from high amplification bias and errors. Here, we describe Digital-WGS, a sample preparation platform that streamlines high-performance single-cell WGS with automatic processing based on digital microfluidics. Using the method, we provide high single-cell capture efficiency for any amount and types of cells by a wetted hydrodynamic structure. The digital control of droplets in a closed hydrophobic interface enables the complete removal of exogenous DNA, sufficient cell lysis, and lossless amplicon recovery, achieving the low coefficient of variation and high coverage at multiple scales. The single-cell genomic variations profiling performs the excellent detection of copy number variants with the smallest bin of 150 kb and single-nucleotide variants with allele dropout rat