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Frontiers | Downregulation of CD45 Signaling in COVID-19 Patients Is Reversed by C24D, a Novel CD45 Targeting Peptide

CD45, the predominant transmembrane tyrosine phosphatase in leukocytes, is required for the efficient induction of T cell receptor signaling and activation. Various studies have demonstrated that viruses can interfere with the functions of CD45 and that patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are immune-suppressed. We recently reported that the CD45-intracellular signals in peripheral blood mononuclear cells (PBMCs) of triple negative breast cancer (TNBC) patients are inhibited. We also reported that C24D, an immune modulating therapeutic peptide, binds to CD45 on immune-suppressed cells and resets the functionality of the immune system via the CD45 signaling pathway. Given the similarity between the role of CD45 in viral immune suppression, reported by others, and our findings on TNBC, we hypothesized that the C24D peptide may have a similar “immune-resetting” effect. We tested this hypothesis by comparing the CD45 intracellular signaling in PBMC

7 top-rated lab products awarded new Seals of Quality

Most loved by scientists: 7 top-rated lab products awarded new Seals of Quality at Cancer & Immunology Research Summit 2021 Editorial Article: Most loved by scientists: 7 top-rated lab products awarded new Seals of Quality at Cancer & Immunology Research Summit 2021 From DNA extraction kits to pipettes and imaging systems, find out the latest products to join the exclusive ranks of lab equipment most loved by scientists across the world 14 May 2021 There are four levels of Seal of Quality Platinum, Gold, Silver, Bronze which are allocated to products based on the number of reviews they receive from scientists and the average rating of those reviews

7 top-rated lab products awarded new Seals of Quality

Most loved by scientists: 7 top-rated lab products awarded new Seals of Quality at Cancer & Immunology Research Summit 2021 Editorial Article: Most loved by scientists: 7 top-rated lab products awarded new Seals of Quality at Cancer & Immunology Research Summit 2021 From DNA extraction kits to pipettes and imaging systems, find out the latest products to join the exclusive ranks of lab equipment most loved by scientists across the world 11 May 2021 There are four levels of Seal of Quality Platinum, Gold, Silver, Bronze which are allocated to products based on the number of reviews they receive from scientists and the average rating of those reviews

Discover the latest products to receive Seals of Quality

The Magnificent Seven: Top-rated lab products awarded new Seals of Quality at Virtual Analytical Summit 2021 Editorial Article: The Magnificent Seven: Top-rated lab products awarded new Seals of Quality at Virtual Analytical Summit 2021 From plasmid isolation kits to infrared imaging systems, find out the latest products to join the exclusive ranks of lab equipment most loved by scientists across the world 23 Feb 2021 There are four levels of Seal of Quality Platinum, Gold, Silver, Bronze which are allocated to products based on the number of reviews they receive and the average rating of those reviews The seven latest laboratory products to win a coveted Seal of Quality have been revealed at the SelectScience

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