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This Biotech Brief discusses the significance of cytokine storms and methods and justifications for monitoring inflammatory mediators to prevent poor clinical outcomes, choose appropriate interventions, and reduce mortality. Pathogens, autoimmune and malignant diseases, genetic disorders, and some therapeutic interventions can lead to life-threatening systemic inflammatory syndromes cytokine release syndrome (CRS) or cytokine storm (CS) that are characterized by is a massive release of cytokines due to excessive activation of immune cells.
2Informatic Unit, INMEDIT SAS and Faculty of Engineering, University of Cartagena, Cartagena, Colombia
3Clinica Respiratoria y de Alergias, Cartagena, Colombia
4Departamento de Investigaciones, Fundación Cardioinfantil, Bogotá, Colombia
5Research Department - CINEUMO, Fundación Neumológica Colombiana, Bogotá, Colombia
6Research Department and Specialization Program in Pulmonology, Universidad de la Sabana, Bogotá, Colombia
Background: Chronic obstructive pulmonary disease (COPD) is associated with increased risk of severe COVID-19, but the mechanisms are unclear. Besides, patients with severe COVID-19 have been reported to have increased levels of several immune mediators.
Methods: Ninety-two proteins were quantified in 315 plasma samples from 118 asthmatics, 99 COPD patients and 98 healthy controls (age 40-90 years), who were recruited in Colombia before the COVID-19 pandemic. Protein levels were compared between each disease group and healthy controls. Significant prote