New research has discovered an important breakthrough that may overcome cancer treatment resistance. The immune system has a naturally occurring brake that tells the body to silence key killer immune cells called CD8+ T-cells as a safeguard to restrain excessive immune responses. Cancer cells are known to exploit this process, called exhaustion, by hijacking the immune system at this off-switch to dampen down the immune attack on cancer, enabling cancer growth.
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While current vaccines direct antibodies at parts of the virus that can easily mutate, the new approach is to target a tiny part of the virus that cannot afford to change.