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Author summary Why was this study done? ➢ The burden of colorectal cancer (CRC) in China has been growing in recent years. ➢ More specific selection of individuals to undergo colonoscopy, based on both questionnaire-based risk assessment and fecal immunochemical test (FIT) results, could result in more efficiency allocation of colonoscopy resources. ➢ There is limited evidence on the colonoscopy screening yield when combining FITs and risk assessment through questionnaires. What did the researchers do and find? ➢ We calculated the baseline screening yield, participation, and cost per case detected in a national CRC screening program with a combined questionnaire-based risk assessment–FIT strategy. ➢ The baseline screening yield and participation rate were improved in the combined risk assessment–FIT group compared with risk factor assessment only group. ➢ The cost per CRC detected was $24,849 by the combined risk factor–FITs strategy, which was much

France generalUnited statesAadela chaudhuriCancer screening program in urban china canInternational classification of diseasesUnion medical collegeAsia pacific working groupMinistry of industryChinese academy of medical sciencesNational cancer preventionCancer screening program in urban chinaNational natural science foundation of china grantUnited states department of veterans affairsChina national cancer center hospitalWashington university in st louisInnovation fund for medical science grant