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Frontiers | Extracellular Vesicle Mediated Tumor-Stromal Crosstalk Within an Engineered Lung Cancer Model

1 1Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, United States 2Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, United States 3Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, United States 4Department of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL, United States Tumor-stromal interactions within the tumor microenvironment (TME) influence lung cancer progression and response to therapeutic interventions, yet traditional in vitro studies fail to replicate the complexity of these interactions. Herein, we developed three-dimensional (3D) lung tumor models that mimic the human TME and demonstrate tumor-stromal crosstalk mediated by extracellular vesicles (EVs). EVs released by tumor cells, independent of p53 status, and fibroblasts within the TME mediate

Octopuses are already adapting to climate change and rising acidification in ocean: Study

Octopuses are Already Adapting Climate Change and Rising Levels of CO2 in Ocean: Study

Octopuses are Already Adapting Climate Change and Rising Levels of CO2 in Ocean: Study FOLLOW US ON: Climate crisis and global warming are changing our environment in not a good way and a few animals might be adapting to it already. A study conducted by Walla Walla University, in a collaboration with researchers from La Sierra University, studied how the changing nature of oceans with rising temperature is affecting octopuses. Physiological and Biochemical Zoology Journal by University of Chicago Press Journals is titled, ‘Impact of Short- and Long-Term Exposure to Elevated Seawater Pco2 on Metabolic Rate and Hypoxia Tolerance in Octopus rubescens’. A team of four scientists studied how ocean acidification, which is the process of rising carbon dioxide levels in seawater, is affecting the metabolism of octopuses. The team comprised scientists from Department of Biological Sciences of Walla Walla University, Kirt L. Onthank, Lloyd A. Trueblood, Taylir Schrock-Duff and Lydia G.

Some octopus species appear to be coping well with increase in ocean acidity, for now- Technology News, Firstpost

Some octopus species appear to be coping well with increase in ocean acidity, for now While the species may be able to acclimate to near-term ocean acidification, the environmental effects of acidification and hypoxia may be challenging. Jan 15, 2021 16:36:20 IST A new study has now tested the effects of ocean acidity on octopuses. The study, conducted by the Walla Walla University, in collaboration with La Sierra University, was published in  Physiological and Biochemical Zoology journal. The collaborative study provides new insights to how activities impact the world and how it adapts in response. The study focused on the metabolic rate of octopuses exposed to water acidified due to CO2 and the changes it brought about in the animals.

Scientists Study Impacts of Acidic Water on Octopuses

Close Recent research conducted at Walla Walla University, by an alliance of researchers from Walla Walla University and La Sierra University, studied the impacts of acidic water on octopuses, possibly bringing new understanding into how activities affect the world and the way the world itself is adjusting in response. According to Physics.org, the study titled, Impact of Short- and Long-Term Exposure to Elevated Seawater PCO2 on Metabolic Rate and Hypoxia Tolerance in Octopus rubescens focused on octopuses metabolic rate to water acidified by carbon dioxide, as well as the changes it made to animals. Essentially, CO2 is the key indicator of the oceans growing acidity since much of the gas emitted into the air by humans gets dissolved into the seawater.

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