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Does Treatment With Systemic Estrogen Reduce Nocturia, or Waking to Urinate?
Nocturia is caused by the loss of estrogen, which causes bladder dysfunction, night sweats, sleep disorders, and alters kidney function. The efficacy of hormone therapy (HT or HRT) on menopause-related nocturia has not been studied much. While topical vaginal estrogen has been shown in past studies to help reduce symptoms linked with the genitourinary syndrome of menopause (GSM), the authors of the new study wanted to look at the effect of systemic estrogen as well, including the effects of other hormone combinations and the new therapy called tissue-selective estrogen complex (TSEC) on nocturia.