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SARS-CoV-2 suppresses host innate immunity SARS-CoV-2, the virus that causes COVID-19, blocks the processes of innate immune activation that normally direct the production and/or signaling of type I interferon (IFN-I) by the infected cell and tissues. IFN-I is a key component of host innate immunity that is responsible for eliminating the virus at the early stage of infection, as summarized in a recent review article in Journal of Interferon & Cytokine Research (JICR). By suppressing innate immunity, the virus replicates and spreads in the body unchecked, leading to the disease known as COVID-19. SARS-CoV-2 utilizes various approaches to evade host IFN-I response, including suppression of IFN-I production and IFN-I signaling. Viruses defective in antagonizing IFN-I response, in combination with replication-defective mutations, could potentially be developed as live attenuated vaccine candidates.

Benjamin liuPei yong shiHarry hillRicardo peredaHongjie xiaEmily hendersonJournal of interferon cytokine researchUniversity of texas medical branch at galvestonUniversity of washingtonDepartment of immunologyCytokine researchTexas medical branchInnate immunityImmune diseaseGenetic engineeringSars cov 2