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Candidate found to inhibit malignant melanoma growth: Possible early warning sign for skin cancer

Candidate found to inhibit malignant melanoma growth: Possible early warning sign for skin cancer
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Hisashi motomuraNaho fujiiOsaka metropolitan university graduate school of medicineProfessor hisashi motomuraOsaka metropolitan university graduate school

Candidate found to inhibit malignant melanoma growth

Candidate found to inhibit malignant melanoma growth
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Hisashi motomuraNaho fujiiOsaka metropolitan university graduate school of medicineProfessor hisashi motomuraOsaka metropolitan university graduate school

CD9-positive exosomes inhibit the growth of malignant melanoma, study suggests

Malignant melanoma is a relatively aggressive type of skin cancer. When detected early, it is usually treatable by surgical resection only, but metastases develop often spreading to distant areas.

Naho fujiiEmily hendersonHisashi motomuraCancer researchOsaka metropolitan university graduate school of medicineOsaka metropolitan universityCancer research industryResearch industry focusProfessor hisashi motomuraOsaka metropolitan university graduate schoolOsaka metropolitanMelanoma cellsSkin cancer

Candidate found to inhibit malignant melanoma

Cancer-associated fibroblasts (CAFs) are key factors in the tumor microenvironment, which have been implicated in cancer cell progression. It has also been reported that vesicles called exosomes produced by these CAFs play an important role in cancer progression. An Osaka Metropolitan University research group investigated the effect of CAF-derived exosomes on the growth of malignant melanoma cells. They found that CAF-derived exosomes express CD9 and CD63 transmembrane proteins, and that the CD9-positive exosomes may inhibit the growth of malignant melanoma cells.

Hisashi motomuraNaho fujiiOsaka metropolitan university graduate school of medicineOsaka city universityMethod of researchOsaka prefecture universityAnticancer researchOsaka metropolitan universityProfessor hisashi motomuraOsaka metropolitan university graduate schoolMetropolitan universityOsaka prefectureExosomes derivedCancer associated fibroblasts might inhibitMalignant melanoma