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The durability of vaccine-induced humoral immunity against SARS-CoV-2 in patients with immune-mediated inflammatory diseases (IMIDs) on immunosuppressive therapy is not known. The aim of this study was to compare the persistence of anti-Spike antibodies following two-dose SARS-CoV-2 vaccination between IMID patients and healthy controls and to identify factors associated with antibody decline. IMID patients on immunosuppressive medication enrolled in the prospective observational Nor-vaC study were included. Participants received two-dose SARS-CoV-2 vaccination. Serum collected at two time points following vaccination (first assessment within 6–48 days, second within 49–123 days) were analyzed for antibodies binding the receptor-binding domain (RBD) of the SARS-CoV-2 Spike protein. Multivariable regression models estimated percent reduction in anti-RBD over 30 days and factors associated with reduction. A total of 1108 patients (403 rheumatoid arthritis, 195 psoriatic arthr

Division of rheumatologyDepartment of gastroenterology at akershus university hospitalServices for sensitive dataNorwegian institute of public healthDepartment of immunologyOslo university hospitalHealth research ethics southDiakonhjemmet hospitalAkershus university hospitalRegional committeesHealth research ethics south eastNorwegian institutePublic healthSensitive dataMayo scoreNorwegian immunisation registry