Differences in human, mouse brain cells have important implications for disease research
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UCLA: Differences In Human, Mouse Brain Cells Have Important Implications For Disease Research
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Differences in human, mouse brain cells have important implications for disease research
ucla.edu - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from ucla.edu Daily Mail and Mail on Sunday newspapers.
FINDINGS
In a study of mice, researchers at the UCLA Jonsson Comprehensive Cancer Center have identified a new approach that combines an anti-psychotic drug, a statin used to lower high cholesterol levels, and radiation to improve the overall survival in mice with glioblastoma. Glioblastoma is one of the deadliest and most difficult-to-treat brain tumors. Researchers found the triple combination extended the median survival 4-fold compared to radiation alone.
BACKGROUND
Radiation therapy is part of the standard-of-care treatment regimen for glioblastoma, often helping prolong the survival of patients. However, survival times have not improved significantly over the past two decades and attempts to improve the efficacy of radiotherapy through the use of pharmaceuticals have been hampered by the normal tissue toxicity of the drugs and the inability to penetrate the blood-brain barrier.