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SARS-CoV-2 Omicron Variant Neutralization after mRNA-1273 Booster Vaccination
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Neutralization of SARS-CoV-2 Variants B 1 429 and B 1 351
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by Duke Health April 8, 2021 .
DURHAM –– Two different COVID vaccines are predicted to be protective against a rapidly spreading variant of the SARS-Cov-2 virus that arose in California, reports a Duke Health-led research team. However, the vaccines were found to be less effective against a variant that first emerged in South Africa.
The finding, appearing April 7 as a research letter in the New England Journal of Medicine, tested blood serum samples from people who had received either the Moderna vaccine or a vaccine candidate from Novovax that is yet to be authorized in the U.S.
When the California variant was exposed to serum of people who received both required doses of the Moderna vaccine, a small decline in effectiveness occurred, but the vaccine remained strongly protective.