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Safety and immunogenicity of aerosolised Ad5-nCoV, intramuscular Ad5-nCoV, or inactivated COVID-19 vaccine CoronaVac given as the second booster following three doses of CoronaVac: a multicentre, open-label, phase 4, randomised trial

A heterologous fourth dose (second booster) with either aerosolised Ad5-nCoV or intramuscular Ad5-nCoV was safe and highly immunogenic in healthy adults who had been immunised with three doses of CoronaVac.

Long liUnited statesPeng wanXue wangTao zhuJ clin microbiolHai tao huangCansino biologicsTechnology planNational natural science foundation of chinaElsevier ltdVazyme medical technologyGraphpad prismJiangsu provinceNat medN specific igg

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