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 E-Mail IMAGE: Cre-Controlled CRISPR mutagenesis at work. Left: wild-type sibling with black pigment in melanocytes along the body and in the developing eye. Right: tissue-specific gene inactivation resulting in loss of pigmentation. view more  Credit: © Stefan Hans To discover the function of a gene researchers turn it off and observe the consequences. Often genes have multiple functions that differ depending on a tissue and age. Some genes are essential to growth and turning them off too early can have profound consequences that can make observing other functions impossible. To avoid it, researchers have been using conditional gene inactivation which allows turning a gene off only in a specific tissue or later in development, e.g., in adulthood.

Michael brandVolker kroehneStefan hansJuan sebastian eguigurenJohanna stuckeSandra spieAndreas petzoldGokul kesavanDiana ezhkovaAndreas dahlNature communicationsHealth sciencesJuliane hammerRegenerative therapies dresdenCell biologyமைக்கேல் பிராண்ட்