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Study explains how citrus flavonoid improves recovery for cyclists Supplementation with 2S‐hesperidin for eight weeks can boost recovery after intense exercise by improving oxidative and inflammatory status, according to a new study. Hesperidin, a flavonoid found in citrus fruits, offers antioxidant and anti‐inflammatory properties and has been found to modulate leukocyte gene expression, therefore showing a nutri‐genomic effect​. The antioxidant effect of hesperidin is mainly related to its radical scavenging capabilities, as well as the increase in antioxidant cellular defense catalase (CAT), superoxide dis‐ mutase (SOD), reduced glutathione (GSH) and oxidized glutathione (GSSG) via the nuclear respiratory factor 2 (NRF2) signaling pathway​. Its anti‐inflammatory effect is produced by a decrease in inflammatory markers, such as nuclear factor kappa B (NF‐κB), interleukin 6 (IL6), tumor necrosis α (TNFα) and inducible nitric oxide

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