The Board of the Global Fund to Fight AIDS, Tuberculosis and Malaria (the Global Fund) held its 51st meeting this week in Geneva, Switzerland. While anticipating record disbursements this year, with an unprecedented pace of investment in resilient and sustainable systems for health (RSSH) and pandemic preparedness and response (PPR), the Board repeatedly acknowledged the numerous challenges – including climate change, conflict, displacement, geopolitics, the economic situation, and in particular, the erosion of human rights and gender equality – that undermine the Global Fund partnership’s ability to end the three diseases by 2030.