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New protocol can develop safe, efficient pluripotent stem cell-based therapies for macular degeneration

As we age, so do our eyes; most commonly, this involves changes to our vision and new glasses, but there are more severe forms of age-related eye problems.

New zealandAlex ledererEmily hendersonNorthern stockholm animal experimental ethics committeeKarolinska institute swedenLife sciences independent researchGioele la mannoSciences independent researchProfessor fredrik lannerKarolinska instituteStem cellNorthern stockholm animal experimental ethicsMacular degenerationStem cellsAge related macular degenerationAnimal model

Streamlining Stem Cells to Treat Macular Degeneration

A new protocol for differentiating human embryonic stem cells to RPE cells could be a safe and effective approach for treating age-related macular degeneration.

New zealandAlex ledererNik papageorgiouNovo nordiskNorthern stockholm animal experimental ethics committeeUniversity of california san franciscoKarolinska institute swedenLife sciences independent researchSciences independent researchProfessor fredrik lannerKarolinska instituteStem cellNorthern stockholm animal experimental ethicsCalifornia sanGioele la mannoNeuroscience newsletter

Cell s production of lipids can be a key factor in determining cell fate

How does a cell "decide" what type of cell to become? The question of "cell fate" has been explored for decades now, especially in the context of stem cell biology, but there are still gaps in our understanding.

Giovanni dangeloEmily hendersonSchool of life sciencesGioele la mannoGiovannid angeloLife sciencesCell biology

Molecular atlas reveals how brain cells develop

Date Time Molecular atlas reveals how brain cells develop Using a combination of powerful sequencing techniques and mathematical methods, EPFL researchers have traced the genetic programs that direct the development of each cell in the brain. This molecular map could help researchers to understand how the brain develops and provide insights into a range of conditions, including brain tumors and neurodevelopmental disorders. As the fertilized egg divides, initially undifferentiated cells take on specific functions, becoming more distinct as different tissues and organs emerge. Understanding how hundreds of disparate cell types arise has proven difficult, largely because scientists have lacked the technologies to capture cellular decision making over time.

Karolinska instituteLaboratory of neurodevelopmental systems biologyLife sciences independent researchGioele la mannoNeurodevelopmental systems biologySciences independent research

A molecular map reveals the development of each cell in the brain

A molecular map reveals the development of each cell in the brain
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Karolinska instituteLaboratory of neurodevelopmental systems biologyGioele la mannoNeurodevelopmental systems biology