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The link between fluoroquinolone antibiotics and aortic aneurysm (AA) was further strengthened by analysis of a U.S. commercial claims database.
Incidence of AA formation or dissection reached 7.5 per 10,000 prescription fills for fluoroquinolones at 90 days compared with 4.6 per 10,000 fills for comparator antibiotics (HR 1.20, 95% CI 1.17-1.24), according to Melina Kibbe, MD, and colleagues of the University of North Carolina at Chapel Hill. The study was published online in
JAMA Surgery, where Kibbe is an editor.
Patients filling prescriptions for these medications were also more likely to undergo aneurysm repair (HR 1.88 vs other antibiotics, 95% CI 1.44-2.46).
The study suggests fluoroquinolone use should be pursued with caution in all adults, not just in high-risk individuals as recommended by the current FDA black box warning, Kibbe s group wrote.