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Investegate |BioNTech SE Announcements | BioNTech SE: Pfizer and BioNTech Publish Results of Study Showing COVID-19 Vaccine Elicits Antibodies that Neutralize Pseudovirus Bearing the SARS-CoV-2 U K Strain Spike Protein in Cell Culture

Investegate announcements from BioNTech SE, Pfizer and BioNTech Publish Results of Study Showing COVID-19 Vaccine Elicits Antibodies that Neutralize Pseudovirus Bearing the SARS-CoV-2 U.K. Strain Spike Protein in Cell Culture

New yorkUnited statesSouth africaUnited kingdomSouth africanSylke maasChuck trianoAmy roseFosun pharmaCenters for diseaseDrug administrationBayer animal healthExchange commissionPfizer incRoche groupVaccine administration under emergency use authorization

BioNTech SE: Pfizer and BioNTech Publish Results of Study Showing COVID-19 Vaccine Elicits Antibodies that Neutralize Pseudovirus Bearing the SARS-CoV-2 U K Strain Spike Protein in Cell Culture

BioNTech SE: Pfizer and BioNTech Publish Results of Study Showing COVID-19 Vaccine Elicits Antibodies that Neutralize Pseudovirus Bearing the SARS-CoV-2 U.K. Strain Spike Protein in Cell Culture Pfizer Inc.and submitted to a peer-reviewed journal. The B.1.1.7 lineage is a rapidly spreading variant of SARS-CoV-2 initially detected in the United Kingdom that carries a larger than usual number of genetic changes with 10 mutations located in the spike protein. BioNTech and Pfizer have previously published data from an in vitro studythat evaluated one of the key mutations (N501Y) in the U.K. strain, which is also shared by the South African strain. That study showed efficient neutralization of the N501Y mutated spike bearing virus by sera of individuals who had received the Pfizer-BioNTech COVID-19 vaccine.

New yorkUnited statesSouth africaUnited kingdomSouth africanSylke maasChuck trianoAmy roseFosun pharmaCenters for diseaseDrug administrationBayer animal healthExchange commissionPfizer incRoche groupVaccine administration under emergency use authorization

BioNTech SE: Pfizer and BioNTech Provide Data from German Phase 1/2 Study Further Characterizing Immune Response Following Immunization with Lead COVID-19 Vaccine Candidate BNT162b2

(2) Analysis of 37 participants immunized with BNT162b2 showed a broad immune response with SARS-CoV-2-specific neutralizing antibodies, T H1 type CD4+ T cells, and strong expansion of CD8+ T cells of the early effector memory phenotype All vaccinated participants demonstrated neutralizing antibody as well as T cell responses. T cell responses were directed against multiple regions of the spike protein, including the RBD, suggesting immune recognition of multiple independent epitopes Data confirm previous findings from the U.S. trial demonstrating a good safety profile and robust induction of antibody responses with a longer follow-up period of 85 days Antibodies generated in trial subjects were able to neutralize

Saudi arabiaAndy widgerKathrinu jansenEpstein barrFosun pharmaSylke maasBiontech covidChuck trianoUgur sahinVaccine administration errorsHead of vaccine research development at pfizerBayer animal healthExchange commissionPfizer incEuropean medicines agencyRoche group

Pfizer, BioNTech COVID-19 vaccine candidate study in Germany support safety profile

Pfizer, BioNTech COVID-19 vaccine candidate study in Germany support safety profile
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