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San Francisco is a double-digit home favorite over a shorthanded New York team on Thursday Night Football.

New yorkUnited statesSan franciscoAndrew thomasDaniel jonessSaquon barkleyChristian mccaffreyDeebo samuelDarren wallerGeorge kittlesJalin hyattMatt breidaBrandon aiyukLos angelesMatthew staffordDaniel jones