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Secret pioneer: Codebreaker explores life of woman who helped bring down spies, gangsters

Yet this suburban wife and mother was never fully credited with her work – until now. American Experience is presenting “The Codebreaker,” which delves into Friedman’s life. The documentary will air at 8 p.m. Monday, Jan. 11, on New Mexico PBS. Friedman Family Portrait. Washington, D.C., 1930s. (Courtesy of George C. Marshall Foundation Library) Chana Gazit is the filmmaker behind the documentary. “When I do films like this, I always feel that I live with the person,” Gazit says. “I loved living with Elizebeth Friedman. It was quite amazing.” Gazit says Friedman lived a secret double life that would only come to light decades after her death, when classified government files were unsealed.

Obesity Impairs Immune Cell Function in Cancer, Triggers Tug-of-War for Fuel

Obesity Impairs Immune Cell Function in Cancer, Triggers Tug-of-War for Fuel December 10, 2020 Source: Science Artwork/Science Photo Library/Getty Images Research by a Harvard Medical School (HMS)-led research team has uncovered a new mechanism by which obesity can interfere with the immune system’s ability to fight cancer. Their studies demonstrated how, in tumor-bearing mice fed a high-fat diet, cancer cells reprogram their metabolism in response to the increased fat availability, so they can better consume energy-rich fat molecules, which then deprives tumor-killing T cells of fuel and accelerates tumor growth. The cancer cells effectively outcompete the immune cells in the battle for fuel, leading to reduced numbers and activity of CD8+ T cells in the tumor microenvironment (TME). Because CD8+ T cells are the main weapon used by immunotherapies that activate the immune system against cancer, the study results could point to potential new strategies for improving these treatm

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