Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) causes severe pneumonia. Previous reports found that CA-MRSA producing the Panton-Valentine leukocidin (PVL) or toxic shock syndrome toxin-1 (TSST-1) triggered severe necrotizing pneumonia. However, other toxins and genetic factors responsible for CA-MRSA pneumonia are rarely analyzed in Japan. In this study, we performed whole-genome sequencing (WGS) to analyze the clinical features of CA-MRSA genetically. As a result, we identified a strain with a rare sequence-type of MRSA.
Herein, we present a case of CA-MRSA pneumonia in a 64-year-old woman. Her condition improved rapidly with vancomycin therapy. Draft WGS led to identifying the genotype and virulence factors and showed that the strain was a rare sequence-type of MRSA with the following characteristics: staphylococcal cassette chromosome mec (SCCmec) type IV, sequence type 121, exfoliative toxin A-positive, and specific staphylococcal protein A type t51
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The number of people hospitalized with covid-19 in Arkansas fell Tuesday for the second time in three days as Gov. Asa Hutchinson pointed to further signs that the wave of infections caused by the rapidly spreading omicron variant has started to recede.
The number of people hospitalized with covid-19 in Arkansas fell Tuesday for the second time in three days as Gov. Asa Hutchinson pointed to further signs that the wave of infections caused by the rapidly spreading omicron variant has started to recede.