Major migration events in Holocene Eurasia have been characterized genetically at broad regional scales1–4. However, insights into the population dynamics in the contact zones are hampered by a lack of ancient genomic data sampled at high spatiotemporal resolution5–7. Here, to address this, we analysed shotgun-sequenced genomes from 100 skeletons spanning 7,300 years of the Mesolithic period, Neolithic period and Early Bronze Age in Denmark and integrated these with proxies for diet (13C and 15N content), mobility (87Sr/86Sr ratio) and vegetation cover (pollen). We observe that Danish Mesolithic individuals of the Maglemose, Kongemose and Ertebølle cultures form a distinct genetic cluster related to other Western European hunter-gatherers. Despite shifts in material culture they displayed genetic homogeneity from around 10,500 to 5,900 calibrated years before present, when Neolithic farmers with Anatolian-derived ancestry arrived. Although the Neolithic transitio
were made to the cell s dna, and they were then armed to fight her cancer. base editing is part of a genetic revolution, which is transforming our understanding of human biology. it is an incredibly precise tool, with huge potential to treat and possibly cure a range of diseases, especially disorders of the blood. ten children with t cell leukaemia will have treatment as part of a clinical trial. part of a clinical trial. there are enormous part of a clinical trial. there are enormous amounts part of a clinical trial. there are enormous amounts of - part of a clinical trial. there are l enormous amounts of innovation part of a clinical trial. there are - enormous amounts of innovation going on, in terms of how we can use these new tools to manipulate and change bits of dna, and our applications are to queue your diseases. there is enormous potential to do that across the board. # ., ., the board. the board- # home grown alligator, see the board- # home grown alligator, see yo
you breathe in and breathe out. thank you, that s a good one. so in may, she received a world first therapy. it is extremely exciting. so obviously, this is a new field in medicine and it s fascinating that we can redirect the immune system to fight cancer. and i think that s a revolution in our field. alyssa s immune system couldn t clear her cancer, so she was given donor cells, which had been tweaked using a new technique called base editing. in the lab, three precise changes were made to the cells dna, and they were then armed to fight her cancer. base editing is part of a genetic revolution, which is transforming our understanding of human biology. it is an incredibly precise tool with huge potential to treat and possibly cure a range of diseases, especially disorders
and i think that s a revolution in our field. alyssa s immune system couldn t clear her cancer, so she was given donor cells, which had been tweaked using a new technique called base editing. in the lab, three precise changes were made to the cells dna, and they were then armed to fight her cancer. base editing is part of a genetic revolution, which is transforming our understanding of human biology. it is an incredibly precise tool with huge potential to treat and possibly cure a range of diseases, especially disorders of the blood. ten children with t cell leukaemia will have the treatment as part of a clinical trial. it s a very fast moving area of science. there s enormous amounts of innovation going on in terms of how we can use these new tools to manipulate and change bits of dna. and our applications
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