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PPIs were generally not associated with an increased risk for mortality due to major causes in a novel analysis accounting for potential protopathic bias.

United statesDavid johnsonAndrewt chanEastern virginia school of medicineHarvard medical schoolNurse health studyHealth professionals studyMassachusetts general hospitalMedscape medicalHealth professionals follow upLag hazard ratioYear lag hazard ratioGenerally safe whenEastern virginia school