Neuroscientists have to choose between seeing the entire brain in low resolution or seeing a small piece of it in high resolution but a new technique known as FLARE could bring that dream one step closer to reality.
Whereas existing tagging techniques require hours to activate, the FLiCRE tagging process takes just minutes. The researchers also designed FLiCRE so that they can use standard genetic sequencing to find the cells in which FLiCRE activated. This allows them to study tens of thousands of cells at once, while other techniques tend to require the analysis of multiple microscopic images that each contain hundreds of cells.