In this article, Thermo Fisher Scientific compares on-line gas chromatography and mass spectrometry, touching upon the benefits, drawbacks and situational use of each.
A number of challenging process applications in the petrochemical, iron and steel, and biotechnology industries can be solved by this online process mass spectrometer and process gas analyzer.
Monitoring Pharmaceutical Solvent Drying Processes
Image Credit: Thermo Fisher Scientific – Environmental and Process Monitoring Instruments
In a number of pharmaceutical processes, one of the key stages is the partial or complete removal of a solvent, or solvents, from an intermediate or product. The drying process needed can happen in a number of process vessels, including tray dryers, vacuum dryers, and rotary dryers.
The success of the drying process was measured upon conclusion by simply taking a sample for laboratory analysis until now.
Organic solvent concentrations in the active pharmaceutical ingredient (API), or intermediate, were measured by gas chromatography; residual water levels were usually investigated by carrying out a Karl Fischer titration.