Scientists have long known that the cells’ ‘protein destruction machine’, the proteasome, plays a crucial role in protein clearance within the brain. However, a new study published in Science has revealed that its essential component, the 19s regulatory particle, has an independent "moonlighting" role at synapses, and thus might offer new opportunities in the diagnosis and treatment of a range of neurological disorders.
Scientists have long known that the cells’ ‘protein destruction machine’, the proteasome, plays a crucial role in protein clearance within the brain. However, a new study published in Science has revealed that its essential component, the 19s regulatory particle, has an independent "moonlighting" role at synapses, and thus might offer new opportunities in the diagnosis and treatment of a range of neurological disorders.