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Blocking Notch signaling pathway could reverse age-related bone loss

A cellular signal essential to the development of the skeleton increases during aging to weaken bones, finds a new study in mice.

New yorkUnited statesChristopher parkAristotelis tsirigosRalf adamsPhilipp leuchtLukasz witekMohamed aliDanielle ellisBackialakshmi dharmalingamSophie morganiPaulo el parenteVasudev nayakMalissa ramsukhZiyan linLauren gillinov

Blocking stem cell signal restores bone healing in aging mice

Blocking a signaling pathway called Notch in skeletal stem cells in mice restored bone-healing ability lost during aging.

New yorkUnited statesPhilipp leuchtBone researchMax planck institute for molecular biomedicineYork university langone healthIsaac perlmutter cancer centerNational institutes of healthYork stem cell foundationNew york university langoneLindsey remarkMax planck instituteMolecular biomedicineNational institutesFrank zarb familyNew york stem cell foundation

Blocking Abnormal Stem Cell Signal during Aging Lessens Related Bone Loss

/PRNewswire/ A cellular signal essential to the development of the skeleton increases during aging to weaken bones, finds a new study in mice. The study,.

Christopher parkNew yorkUnited statesKevin leclercAristotelis tsirigosLukasz witekMohamed aliSophie morganiPhilipp leuchtPaulo el parenteRalf adamsSooyeon leeAlesha castilloVasudev nayakGregory williamsLauren gillinov

Blocking abnormal stem cell signal during agi

A cellular signal essential to development of the skeleton increases abnormally during aging to weaken bones.

New yorkUnited statesChristopher parkPaulo el parenteAlesha castilloKevin leclercRalf adamsZiyan linPhilipp leuchtMohamed aliSooyeon leeLauren gillinovMalissa ramsukhBackialakshmi dharmalingamAristotelis tsirigosSophie morgani

Blocking Abnormal Stem Cell Signal during Aging Lessens Related Bone Loss

Blocking Abnormal Stem Cell Signal during Aging Lessens Related Bone Loss
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Christopher parkNew yorkUnited statesRalf adamsLukasz witekMohamed aliVasudev nayakBackialakshmi dharmalingamAlesha castilloLauren gillinovSophie morganiMalissa ramsukhAristotelis tsirigosZiyan linGregory williamsSooyeon lee