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AI reveals current drugs that may help combat Alzheimer’s New treatments for Alzheimer’s disease are desperately needed, but numerous clinical trials of investigational drugs have failed to generate promising options. Now a team at Harvard-affiliated Massachusetts General Hospital (MGH) and Harvard Medical School (HMS) has developed an artificial intelligence-based method to screen currently available medications as possible treatments for Alzheimer’s disease. The method could represent a rapid and inexpensive way to repurpose existing therapies into new treatments for this progressive, debilitating neurodegenerative condition. Importantly, it could also help reveal new, unexplored targets for therapy by pointing to mechanisms of drug action.

United statesFrank wilkins jrArtem sokolovMark albersSteve rodriguezMassachusetts centerNature communicationsDepartment of neurologyNational institute onLaboratory of systems pharmacologyEisai incHarvard medical schoolHoly cross health in fort lauderdaleGlencoe softwareHarvard catalyst program for faculty developmentHarvard affiliated massachusetts general hospital