Latest Breaking News On - Foundation of science - Page 3 : comparemela.com

163 are also involved in resistance to cisplatin, temozolomide and 5-fluorouracil via altering glycolysis in gastric cancer, glioblastoma and CRC, respectively. Interestingly, Fu et al reported that lncRNA plasmacytoma variant translocation 1 (PVT1) maintains Myc expression in Sjögren’s syndrome. This expression regulates proliferation and immune effects of CD4 + T cells by controlling glycolytic metabolism. 164 Investigating the role of the PVT1-T cell glycolysis axis in tumor models may provide a novel insight for improving T cell-based immunotherapy. The important role of lncRNAs-mediated glucose metabolic reprogramming in cancer adjuvant therapy, as discussed above, makes them promising targets for treating cancers. Several studies have revealed that siRNA, antisense oligonucleotides (ASOs) and clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9) may be promising methods of targeting lncRNAs.

Gong longHali longCao longChen longAsong longSouth koreaWum lncBiochim biophys actaSonveauxp monocarboxylateAl hasawiEl amraniChemother pharmacolChengdu university of traditional chinese medicineFoundation of scienceTechnology department of sichuan provinceEthics approval