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Royal Society of Chemistry will make all its journals open access
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Nobel honors molecule builders who made chemistry easier and greener
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By Laura Cooper2021-05-10T13:28:00+01:00
Japan-based chemists have developed a strategy for activating an anticancer prodrug that takes advantage of elevated levels of endogenous acrolein at tumour sites. This could reduce side effects, which are often serious drawbacks of cancer therapy, by targeting the drug release directly into the cancerous tissue to avoid healthy cells.
Many researchers in the field of chemical biology are combining bioorthogonal chemistry, where reactions take place inside living things without interfering with normal biological processes, with click chemistry to convert prodrugs into active drugs.
The copper-catalysed cycloaddition reaction between acetylene and azide is a well-known example of click chemistry. Katsunori Tanaka from RIKEN and his team were looking for similar reactions that would be applicable to in vivo models when they serendipitously found that aryl azides react with acrolein. Acrolein is a small unsaturated aldehyde which is produced
New president of EuChemS Floris Rutjes
Floris Rutjes, a synthetic organic chemist who is vice-dean at Radboud University in the Netherlands and also vice-president of the Royal Netherlands Chemical Society, took the helm of the European Chemical Society (EuChemS) on 1 January. Rutjes assumed his new role as head of the umbrella organisation for European chemical societies after being elected at the EuChemS general assembly in Bucharest, Romania in October 2020. He succeeds Pilar Goya, a research professor at the Spanish Research Council’s Institute of Medical Chemistry in Madrid, and will remain in post until the end of 2023.
Rutjes’ work focuses on developing new and sustainable synthesis methodology, designing and synthesising biologically active small molecules, as well as new probes for bio-orthogonal conjugation, and continuous flow chemistry in microreactor systems. He earned a PhD in organic chemistry from the University of Amsterdam in 1993, and did his postdoctoral wor