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Elizabeth Plimack, MD, and Robert Motzer, MD, explain their preferences between TKI-IO combination therapies for patients with advanced RCC considering efficacy, side effects, and specific patient factors.

Elizabeth plimackRobert motzerEvolving treatmentsAdvanced renal cell carcinomaPlus pembrolizumabFirstline treatmentRenal cell carcinomaMetastatic renal cell cancerDose reductionAdjuvant therapyToxicity managementBlood pressureThyroid toxicityLiver toxicityHand foot syndrome