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Presurgical Keytruda Plus Chemotherapy Improves Response for Some With Breast Cancer

Neoadjuvant Keytruda plus chemotherapy followed by adjuvant Keytruda plus endocrine therapy generated a statistically significant increase in pathologic complete response compared to pre-surgical placebo and chemotherapy followed by adjuvant Keytruda and endocrine therapy for patients with high-risk, early-stage, estrogen receptor–positive, HER2-negative breast cancer.

Fatima cardosoChampalimaud clinical centerBreast cancer

Pembrolizumab With Chemotherapy Before Surgery Significantly Improves Response Rate in Patients With Breast Cancer

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United statesFatima cardosoAditya bardiaGursel aktanPembrolizumab keytrudaCancer centerHarvard medical schoolBreast unit of the champalimaud clinical centreMerck research laboratoriesBreast unitChampalimaud clinical centreMassachusetts general hospitalMassachusetts general cancer center

Neoadjuvant Pembrolizumab Plus Chemotherapy Boosts pCR in ER+/HER2- Breast Cancer

Neoadjuvant pembrolizumab plus chemotherapy followed by adjuvant pembrolizumab plus endocrine therapy generated a statistically significant increase in pathologic complete response vs neoadjuvant placebo plus chemotherapy followed by adjuvant pembrolizumab and endocrine therapy in patients with high-risk, early-stage, estrogen receptor–positive, HER2-negative breast cancer.

Fatima cardosoBreast unit at champalimaud clinical centerBreast unitChampalimaud clinical centerEastern europeNeoadjuvant pembrolizumabKeynote 756Breast cancer

Merck s Keytruda combination shows promise in late-stage breast cancer study

Merck s Keytruda combination shows promise in late-stage breast cancer study
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Gursel aktanMerck keytrudaFatima cardosoMerck coMerck research laboratories

Pembrolizumab Plus Chemotherapy Led to Pathological Complete Response in Patients with Breast Cancer

The trial was recommended to continue to analyze event-free survival rates, but current results are encouraging for treating estrogen receptor-positive, human epidermal growth factor receptor 2-negative breast cancer.

United statesPembrolizumab keytrudaFatima cardosoGursel aktanBreast unit of the champalimaud clinical centreMerck research laboratoriesData monitoring committeeBreast unitChampalimaud clinical centre