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University Health Network (UHN)

Oncolytic virus plus immunotherapy extends survival in recurrent glioblastoma

The combination of intratumoral DNX-2401 and pembrolizumab appeared safe and provided “notable survival benefits” for select patients with recurrent glioblastoma, according to a study published in Nature Medicine.The phase 1/phase 2 trial did not meet its primary efficacy endpoint of objective response rate; however, the combination conferred a 12-month OS rate of 52.7% — which

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