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En réalité, les pandas sont des parapluies fragiles
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For Shielding Endangered Neighbors, Pandas Make Flimsy Umbrellas
A new study challenges a common hypothesis about how protecting charismatic species also conserves animals that are less well known.
Pandas are an example of what’s called an umbrella species: a charismatic, well-known and endangered animal whose protection benefits an entire ecosystem and all the wildlife therein.Credit.Fang Wang
By Rachel Nuwer
Like many undergraduate biology students, Fang Wang was taught that pandas are a prime example of an umbrella species a charismatic, well-known and usually endangered animal whose protection benefits an entire ecosystem and all the wildlife that lives there.
Credit: MD Anderson Cancer Center
HOUSTON In an effort to address a major challenge when analyzing large single-cell RNA-sequencing datasets, researchers from The University of Texas MD Anderson Cancer Center have developed a new computational technique to accurately differentiate between data from cancer cells and the variety of normal cells found within tumor samples. The work was published today in
Nature Biotechnology.
The new tool, dubbed CopyKAT (copy number karyotyping of aneuploid tumors), allows researchers to more easily examine the complex data obtained from large single-cell RNA-sequencing experiments, which deliver gene expression data from many thousands of individual cells.
CopyKAT uses that gene expression data to look for aneuploidy, or the presence of abnormal chromosome numbers, which is common in most cancers, said study senior author Nicholas Navin, Ph.D., associate professor of Genetics and Bioinformatics & Computational Biology. The tool also helps to i
Credit: The Wistar Institute
PHILADELPHIA (Jan. 12, 2021) Scientists at The Wistar Institute have created an advanced humanized immune system mouse model that allows them to examine resistance to immune checkpoint blockade therapies in melanoma. It has revealed a central role for mast cells. These findings were published today in the journal
Nature Communications.
Checkpoint inhibitors revolutionized therapeutic options for advanced melanoma. However, only a fraction of patients respond to this treatment and some relapse due to reemergence of therapy-resistant lesions. To better understand why some cancers do not respond or become resistant to checkpoint therapies, we need more preclinical models that mimic the human tumor immune environment, said Rajasekharan Somasundaram, Ph.D., a member of The Wistar Institute Melanoma Research Center, who is the first and corresponding author of the paper.
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