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A new “spleen-on-a-chip” microfluidic device can model how the spleen’s filters become clogged by sickled red blood cells, leading to a life-threatening condition known as acute splenic sequestration.

France generalUnited statesZixiang liuSubra sureshJohn higginsGeorge karniadakisAbdoulaye sissokoFuyin zhengMing daoFang kongYuhao qiangNanyang technological universityNational institutes of healthPasteur instituteSingapore nanyang technological universityProceedings of the national academy sciences